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Rozanolixizumab

CAS No. : 1584645-37-3

MCE 站：Rozanolixizumab

产品活性：Rozanolixizumab (UCB7665) 是一种人源化的高亲和力抗人新生儿 Fc 受体 (FcRn) 单克隆抗体 (IgG4P)，用于降低自身免疫和同种免疫疾病中致病性 IgG 的研究。

研究领域：Others

作用靶点：Others

In Vitro: Rozanolixizumab binds to human FcRn ａnd cynomolgus monkey FcRn with a similar affinity at both pH 6.0 (K_d 23 pM ａnd 25 pM, human ａnd cynomolgus monkey, respectively) ａnd pH 7.4 (34 pM ａnd 53 pM, human ａnd cynomolgus monkey, respectively. Rozanolixizumab is observed to inhibit the recycling (IC₅₀ 0.41 nM) of human IgG by human FcRn-transfected MDCK cells in a dose-dependent manner. Recycling of IgG was also inhibits in cynomolgus monkey FcRn-transfected MDCK cells (IC₅₀ 0.98nM).
Rozanolixizumab causes an increase in intracellular IgG AF647.

In Vivo: Intravenous (IV) rozanolixizumab dosing in cynomolgus monkeys demonstrated non-linear pharmacokinetics indicative of target-mediated drug disposition; single IV rozanolixizumab doses (30 mg/kg) in cynomolgus monkeys reduced plasma IgG concentration by 69% by Day 7 post-administration. Daily IV administration of rozanolixizumab (initial 30 mg/kg loading dose; 5 mg/kg daily thereafter) reduced plasma IgG concentrations in all cynomolgus monkeys, with low concentrations maintained throughout the treatment period (42 days).

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