MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Simufilam dihydrochloride

CAS No. : 2480226-06-8

MCE 站：Simufilam dihydrochloride

产品活性：Simufilam dihydrochloride 是一种低毒的，具有口服活性的 filamin A (FLNA) 激活剂。Simufilam dihydrochloride 可优先结合改变的 FLNA，并恢复其天然构象，恢复受体和突触活性，并减少其与 a7nAChR/TLR4 的关联和下游病理作用。Simufilam dihydrochloride 可用于阿尔茨海默症的研究。

研究领域：Others

作用靶点：Others

In Vitro: Simufilam dihydrochloride (1 pM~1 nM) dose-dependently improves NMDA/glycine-induced Arc expression.
Simufilam dihydrochloride (1 nM, 1 hour) largely restores filamin A to its native conformation ａnd is effective in normalizing receptor activities in AD frontal cortices. Simufilam dihydrochloride dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR ａnd TLR4 in both Ab42-treated control ａnd AD hippocampus. Simufilam dihydrochloride reduces Ab42＇s binding affinity for a7nAChR, thereby prevents Ab42＇s signaling ａnd further accumulation on a7nAChRs.

In Vivo: Simufilam dihydrochloride (P.o.; 2 months) restores FLNA to its native conformation. Simufilam dihydrochloride (22 mg/kg; p.o.) robustly reduces FLNAea7nAChR/TLR4 associations. Simufilam dihydrochloride significantly improves spatial memory. Simufilam significantly improves working memory.

相关产品：PEG300  |  SBE-β-CD  |  Corn oil  |  Tween 80  |  D-Lin-MC3-DMA  |  Polyethylene glycol 12-hydroxystearate  |  Lipopolysaccharides  |  JC-1  |  (2-Hydroxypropyl)-β-cyclodextrin  |  Digitonin  |  Methyl-β-cyclodextrin  |  CFSE  |  DTT  |  Biotin  |  3X FLAG peptide TFA  |  O-Propargyl-Puromycin  |  D-Luciferin potassium salt  |  Thiazolyl Blue  |  Monocrotaline  |  Tocofersolan  |  Nile Red  |  IPTG  |  Yoda 1  |  Cremophor EL  |  GsMTx4 TFA  |  FLAG peptide  |  Auxinole  |  Calcein-AM  |  Propidium Iodide

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。