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Antifungal Compound Library

MCE 站：Antifungal Compound Library

The high rates of morbidity ａnd mortality caused by fungal infections are associated with the current limited antifungal arsenal ａnd the high toxicity of the compounds. Additionally, identifying novel drug targets is challenging because there are many similarities between fungal ａnd human cells. The most common antifungal targets include fungal RNA synthesis ａnd cell wall ａnd membrane components, though new antifungal targets are being investigated. Nonetheless, fungi have developed resistance mechanisms, such as overexpression of efflux pump proteins, overexpression ａnd changes in drug targets ａnd biofilm formation, emphasizing the importance of discovering new antifungal drugs ａnd therapies. Due to the limited antifungal arsenal, researchers have sought to improve treatment via different approaches, such as the combination of antifungal drugs, development of new formulations for antifungal agents ａnd modifications to the chemical structures of traditional antifungals, etc. MCE offers a unique collection of 210 compounds with validated antifungal activities. MCE antifungal compound library is an effective tool for drug repurposing screening, combination screening ａnd biological investigation.

Description & Advantages:

•   A unique collection of 210 bioactive anti-fungal compounds for high throughput screening (HTS) ａnd high content screening (HCS).

•   A useful tool for the discovery of anti-fungal drugs.

•   Bioactivity ａnd safety confirmed by preclinical research ａnd clinical trials. Some have been approved by FDA.

•   Structurally diverse, medicinally active, ａnd cell permeable.

•   Detailed compound information with structure, IC₅₀, ａnd brief introduction.

•   Validated NMR ａnd HPLC to ensure high purity ａnd quality.

•   All compounds are in stock ａnd continuously updated.

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。