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Transcription Factor Targeted Library

MCE 站：Transcription Factor Targeted Library

Transcription is the essential first step in the conversion of the genetic information in the DNA into protein ａnd the major point at which gene expression is controlled. Transcription of protein-coding genes is accomplished by the multi-subunit enzyme RNA polymerase II ａnd an ensemble of ancillary proteins, called transcription factors (TFs). Transcription factors play an important role in the long-term regulation of cell growth, differentiation ａnd responses to environmental cues. Deregulated transcription factors contribute to the pathogenesis of a plethora of human diseases, ranging from diabetes, inflammatory disorders ａnd cardiovascular disease to many cancers, ａnd thus these proteins hold great therapeutic potential. MCE offers a unique collection of 768 compounds with validated transcription factor targets modulating properties. MCE transcription factor targeted compound library is an effective tool for researching transcription factors as drug targets as well as modulation of TFs for different therapeutic applications.

Description & Advantages:

•   A unique collection of 768 small molecule compounds with validated transcription factor targets modulating properties.

•   Targeting more than 60 transcription factors, such as AP-1, ATF6, BCL6, NF-κB, etc.

•   A useful tool for the research of transcription factor-related regulation ａnd diseases.

•   Bioactivity ａnd safety confirmed by preclinical research ａnd clinical trials. Some have been approved by FDA.

•   Structurally diverse, medicinally active, ａnd cell permeable.

•   Detailed compound information with structure, IC₅₀, ａnd brief introduction.

•   Validated NMR ａnd HPLC to ensure high purity ａnd quality.

•   All compounds are in stock ａnd continuously updated.

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•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
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