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α-Conotoxin Vc1.1 TFA

CAS No. :

MCE 站：α-Conotoxin Vc1.1 TFA

产品活性：α-Conotoxin Vc1.1 TFA 是一种分离自 Conus victoriae 的二硫键肽，也是一种选择性的 nAChR 拮抗剂。α-Conotoxin Vc1.1 TFA 抑制 α3α5β2，α3β2 和 α3β4 的 IC₅₀ 分别为 7.2 μM，7.3 μM 和 4.2 μM，对其他 nAChR 亚型的抑制作用较小，可用于神经性疼痛的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：nAChR

In Vitro: The α-Conotoxin Vc1.1 is first discovered using a PCR screen of cDNAs from the venom ducts of Conus victoriae. α-Conotoxin Vc1.1 inhibits nicotine-evoked membrane currents in isolated bovine chromaffin cells in a concentration-dependent manner ａnd preferentially targets peripheral nAChR subtypes over central subtypes. The three-dimensional structure of Vc1.1 comprises a small alpha-helix spanning residues Pro6 to Asp11 ａnd is braced by the I-III, II-IV disulfide connectivity seen in other alpha-conotoxins. The cysteine spacing within the sequence of α-Conotoxin Vc1.1 suggests that it is a member of the 4/7 subclass of α-conotoxins, which includes the extensively studied conotoxins MII, EpI ａnd PnIB.

In Vivo: α-Conotoxin Vc1.1 (0.18-18 μg/μL; intramuscular injection; daily; for 7 days; male Sprague-Dawley rats) treatment suppresses pain behaviors ａnd also accelerates functional recovery of injured neurons in CCI rats.

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