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Parstatin(human) TFA

CAS No. :

MCE 站：Parstatin(human) TFA

产品活性：Parstatin(human) TFA 是具有细胞通透性的 PAR-1 凝血酶受体的肽类激动剂，是一种有效的血管生成抑制剂。

研究领域：GPCR/G Protein

作用靶点：Protease-Activated Receptor (PAR)

In Vitro: Parstatin (0-10 µM) increases recovery of LVDP in a concentration-dependent manner. The optimal concentration was 1 µM which produced a 23% recovery of LVDP.

In Vivo: Parstatin (single dose, 1-25 µg/kg, iv) administered prior to ischaemia confers immediate cardioprotection by recruiting the Gi-protein activation pathway including p38 MAPK, ERK1/2, NOS, ａnd KATP channels. Parstatin exerts effects on both the cardiomyocytes ａnd the coronary circulation to induce cardioprotection. This suggests a potential therapeutic role of parstatin in the treatment of cardiac injury resulting from ischaemia ａnd reperfusion.

相关产品：Vorapaxar  |  TRAP-6  |  AZ3451  |  PAR-4 Agonist Peptide, amide TFA  |  SLIGRL-NH2  |  SCH79797 dihydrochloride  |  I-191  |  ENMD-1068 hydrochloride  |  GB-88  |  GB-110 hydrochloride  |  Protease-Activated Receptor-2, amide  |  TFLLR-NH2(TFA)  |  2-Furoyl-LIGRLO-amide  |  FSLLRY-NH2 TFA  |  Parmodulin 2  |  AC-55541  |  tcY-NH2 TFA  |  PZ-128  |  PAR-2-IN-1  |  Protease-Activated Receptor-4  |  Protease-Activated Receptor-1, PAR-1 Agonist TFA  |  Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA  |  AC-264613  |  Atopaxar  |  CBK289001  |  PAR 4 (1-6) (TFA)

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