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RAGE antagonist peptide TFA

CAS No. :

MCE 站：RAGE antagonist peptide TFA

产品活性：RAGE antagonist peptide TFA 是一种晚期糖基化终产物 (RAGE) 拮抗剂。RAGE antagonist peptide TFA 可阻断 RAGE 和几个重要配体 HMGB-1，S100P，S100A4 的结合。RAGE antagonist peptide TFA 具有抗肿瘤和抗炎活性。

研究领域：Neuronal Signaling

作用靶点：Amyloid-β

In Vitro: RAGE antagonist peptide TFA (RAP) reduces the ability of the ligands to stimulate RAGE activation of NFκB in cancer cells in vitro.

In Vivo: RAGE antagonist peptide TFA (RAP, 100 µg) inhibits RAGE-mediated Basal NFκB Activity in PDAC cells in vivo.
RAGE antagonist peptide TFA (RAP) reduces the growth ａnd metastasis of pancreatic tumors ａnd also inhibited glioma tumor growth.
In mice bearing asthma, RAGE antagonist peptide TFA (RAP; 4 mg/kg; i.p.) blunts airway reactivity, airway inflammation ａnd goblet cell metaplasia, ａnd decreases release of Th2 cytokines. RAGE antagonist peptide TFA also reduces total, cytoplasmic ａnd nuclear levels of β-catenin, enhances β-catenin phosphorylation at Ser33/37/Thr41, which triggers ubiquitination, down-regulated expression of β-catenin targeted genes, ａnd tends to keep β-catenin at the cytomembrane, shifting β-catenin from a signalling active pattern to an adhesive function.

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