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NIR-Thiol dinitrobenzenesulfonate

CAS No. :

MCE 站：NIR-Thiol dinitrobenzenesulfonate

产品活性：NIR-Thiol dinitrobenzenesulfonate 是一种可透过细胞的 NIR 荧光硫醇传感器。NIR-Thiol dinitrobenzenesulfonate 在 NIR 区域内同时具有吸收和发射作用。当在 NIR 区域激发时，NIR-Thiol dinitrobenzenesulfonate 对硫醇产生较大的启动 NIR 荧光信号，还能够对活细胞和小鼠中内源性产生的硫醇进行成像。

研究领域：Others

作用靶点：Others

In Vitro: NIR-Thiol dinitrobenzenesulfonate is highly selective to typical small molecular weight biological thiols (Cys, Hcy, ａnd GSH) over other biorelevant species, such as Phe, Gly, Arg, Lys, Tyr, Leu, glucose, Ser, ａnd Val.
To assess the ability of the sensor NIR-Thiol dinitrobenzenesulfonate for NIR imaging of thiols in living cells, the sensor is incubated with living HeLa or Bel 7702 cells, ａnd bright fluorescence is observed. Thus, the sensor appears to be cell membrane permeable ａnd capable of NIR imaging of thiols in living cell. NIR-Thiol dinitrobenzenesulfonate has some prominent features, includinf NIR absorption ａnd emission, rapid response, high sensitivity, excellent selectivity, good cell membrane permeability, ａnd low cytotoxicity.

In Vivo: A different amount (0, 20, 40, or 160 nanomoles) of NIR-Thiol dinitrobenzenesulfonate is injected into the ip cavity of mice. Strong fluorescence is noted for the mice injected with 20 nanomoles of NIR-Thiol dinitrobenzenesulfonate, whereas almost no fluorescence is observed in the control mice without being injected with the sensor. In addition, the mice injected with a higher amount (40 or 160 nanomoles) of NIR-Thiol dinitrobenzenesulfonate provids brighter fluorescence. A very large signal-to-noise contrast ratio (ca. 700-fold enhancement) is observed for the mice injected with 20 nanomoles of NIR-Thiol dinitrobenzenesulfonate. In addition, the signal-to-noise contrast ratio jumped to ca. 2900- or 7400-fold enhancement when the mice are injected with 40 or 160 nanomoles of NIR-Thiol dinitrobenzenesulfonate, respectively.

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