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Otin

CAS No. : 487-49-0

MCE 站：Otin

产品活性：Otin 是一种天然脱氧安息香素，是一种有效的选择性 TRPM3 通道阻断剂，IC₅₀ 为 0.3 μM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

In Vitro: Otin (1-10 μM) completely ａnd reversibly abrogates Ca²⁺ entry ａnd ionic currents through recombinantly expressed TRPM3α2 ａnd block the pregnenolone sulphate-inducible Ca²⁺ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones, indicating biological activity towards endogenously expressed TRPM3.
Oxidative intermediates of Otin may be involved in activating TRPA1, but not in the block of TRPM3 by Otin.

In Vivo: Otin (10 mg/kg, i.p.) treatment completely reverses established Freund＇s Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3^-/- mice is unlikely to be caused by developmental or compensatory mechanisms ａnd suggests that TRPM3 may be a tractable target for inflammatory pain.

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