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Dihydrocapsiate

CAS No. : 205687-03-2

MCE 站：Dihydrocapsiate

产品活性：Dihydrocapsiate 作为二氢 capsinoid 家族的化合物，是一种口服活性 TRPV1 激动剂。Dihydrocapsiate 可用于代谢疾病的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

In Vitro: Dihydrocapsiate (10, 25 ａnd 50 μM; 48 hours; human preadipocytes) does not affect cell viability.
Dihydrocapsiate (10 ａnd 20 μM; 8 days; mature adipocytes) markedly decreases the expression levels of other adipogenic markers (such as SREBP1, FABP4, PLIN1, ADIPOQ ａnd LEPTIN) ａnd inflammatory markers (MCP1 ａnd TNFα), whereas it enhances the expression levels of PGC1α (master regulator of mitochondrial biogenesis) ａnd TBX1 (marker of “brite” cell) .
Dihydrocapsiate (25~200 μM; RAW 264.7 cells) prevents NO release ａnd intracellular ROS generation.

In Vivo: Dihydrocapsiate (2 ａnd 10 mg/kg; p.o.) improves morphometric parameters ａnd insulin levels, prevents high fat diet (HFD)-induced adipocyte size ａnd enhances energy expenditure-related genes in WAT, alleviates HFD-induced hepatic steatosis, prevents HFD-induced fat deposition ａnd enhances mitochondrial biogenesis genes in BAT ａnd improves intestinal morphology ａnd modulates SCFA availability.

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