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Quercetin

CAS No. : 117-39-5

MCE 站：Quercetin

产品活性：Quercetin 是一种天然黄酮类化合物，可激活或抑制许多蛋白质的活性。Quercetin 可激活 SIRT1，也可抑制 PI3K，抑制 PI3Kγ，PI3Kδ，PI3Kβ 的 IC₅₀ 分别为 2.4 μM, 3.0 μM, 5.4 μM。

研究领域：PI3K/Akt/mTOR  |  Autophagy  |  NF-κB  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  Apoptosis

作用靶点：PI3K  |  Autophagy  |  Mitophagy  |  Reactive Oxygen Species  |  Apoptosis

In Vitro: Quercetin is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory ａnd antioxidant properties, ａnd it is being investigated for a wide range of potential health benefits. Quercetin is a PI3K inhibitor with IC₅₀ of 2.4-5.4 μM. Quercetin strongly abrogates PI3K ａnd Src kinases, mildly inhibits Akt1/2, ａnd slightly affected PKC, p38 ａnd ERK1/2. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), ａnd BPAEC DNA synthesis ａnd proliferation.

In Vivo: Combination of Quercetin (75 mg/kg) ａnd 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP ａnd PC-3 cells xenograft tumor growth.

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