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Tepre

CAS No. : 6809-52-5

MCE 站：Tepre

产品活性：Tepre 是一种抗溃疡药，为热休克蛋白 (heat shock proteins) 的诱导剂。

研究领域：Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease

作用靶点：HSP

In Vitro: Tepre is an inducer of HSPs. Tepre (Geranylgeranylacetone, 1 μM) significantly prevents ethanol-induced exfoliation, ａnd reduces lactate dehydrogenase (LDH) release in gastric mucosal cells. Tepre (1 μM) gradually increases HSC70 level, ａnd rapidly accumulates the stress-inducible HSP90, HSP70, ａnd HSP60 concentrations within 30-60 min. Tepre also activates the heat shock factor 1. Tepre (0-20 µM) slightly increases human umbilical vein endothelial cell (HUVEC) viability following irradiation (IR). Tepre (10 µM) exhibits no effects on HUVEC migration ａnd invasion, but enhances HUVEC tube formation ａnd wound healing both with ａnd without IR. Tepre (10 µM) also promotes angiogenesis by inducing VEGF ａnd eNOS expression in HUVECs.

In Vivo: Tepre (200 mg/kg, p.o.) results in the accumulation of HSP70 mRNA in rats, ａnd the accumulation is enhanced by stress addition in the mucosa of Tepre-pretreated rats compared with that of vehicle-pretreated rats. Tepre (200 mg/kg, p.o.) markedly suppresses the ulcer formation after 2- ａnd 4-hour stress loading in rats. Tepre (200 mg/kg daily) induces HSP72 in retinal ganglion cells (RGCs) from rat retinas. Tepre significantly reduces the loss of RGCs (evaluated after intraocular pressure (IOP) elevation), lessens optic nerve damage, decreases the number of TUNEL-positive cells in the RGC layer, ａnd increases HSP72 in a rat model of glaucoma. Tepre (200 mg/kg, p.o.) shows protective effect on radiation-induced intestinal injury in mice.

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