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Paromomycin sulfate

CAS No. : 1263-89-4

MCE 站：Paromomycin sulfate

产品活性：Paromomycin (Aminosidine) sulfate 是一种的广谱氨基糖苷类抗生素 (antibiotic)，具有杀螨杀菌作用，是新霉素 (HY-B0470) 衍生物。Paromomycin sulfate 通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合，使 mRNA 的翻译提前终止，并抑制蛋白质合成。Paromomycin sulfate 可用于细菌和寄生虫感染的研究。

研究领域：Anti-infection

作用靶点：Antibiotic  |  Parasite  |  Bacterial

In Vitro: Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells ａnd reduces the percentage of intracellular C. parvum forms by 99.5% in HCT-8 cells.

In Vivo: Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces ａnd intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected with C. parvum ａnd only 10% of focal inflammation at 200 mg/kg.

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