型号:
产品价格:电议      采购度:1591      原产地:美洲
发布时间:2021/11/4 18:41:52 所属地区:国外 国外
简要描述:
(-)-Epicatechin gallate (Epicatechin gallate) 抑制环加氧酶-1 (COX-1) , IC50 为 μM。
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CAS No. : 1257-08-5
MCE 站:(-)-Epicatechin gallate
产品活性:(-)-Epicatechin gallate (Epicatechin gallate) 抑制环加氧酶-1 (COX-1) , IC50 为 7.5 μM。
研究领域:Immunology/Inflammation | Autophagy | Anti-infection
作用靶点:COX | Autophagy | Virus Protease
In Vitro: (-)-Epicatechin gallate (Epicatechin gallate) exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM.
In Vivo: (-)-Epicatechin gallate (Epicatechin gallate), a component of Rhei Rhizoma, is one of the active components of Onpi-to, a herbal medicine composed of five crude drugs (Rhei Rhizome, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber). Following intravenous injection of (-)-Epicatechin gallate (1.0 mg/kg) in rats, the plasma concentration vs. time curve is fitted in a three compartment model. Pharmacokinetic parameters for plasma Epicatechin gallate (ECG) are measured. ECG has a t1/2α of 0.038 h, a t1/2βof 0.291 h and a t1/2γ of 4.033 h . The CLtot of ECG is 4.19 L/h • kg. The Vdss is 12.39 L/kg.
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更新时间:2024/1/2 10:18:59
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