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Ginsenoside Rc

CAS No. : 11021-14-0

MCE 站：Ginsenoside Rc

产品活性：Ginsenoside Rc 是主要的人参皂甙，Ginsenoside Rc 增强 GABA 受体 A (GABA_A) 介导的离子通道 (I_GABA)电流。 Ginsenoside Rc 还抑制 TNF-α 和 IL-1β 表达。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Apoptosis  |  Immunology/Inflammation

作用靶点：GABA Receptor  |  TNF Receptor  |  Interleukin Related

In Vitro: Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptor_A (GABA_A)-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABA_A receptor. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α ａnd IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 ａnd p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, ａnd HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 ａnd p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 ａnd phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 ａnd 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation.

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