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Ginsenoside Rd

CAS No. : 52705-93-8

MCE 站：Ginsenoside Rd

产品活性：Ginsenoside Rd 抑制 TNFα 诱导的 NF-κB 转录活性，IC₅₀ 为 12.05±0.82 μM。Ginsenoside Rd 抑制 COX-2 和 iNOS mRNA 的表达。Ginsenoside Rd 还抑制 Ca²⁺ 内流。Ginsenoside Rd 抑制CYP2D6，CYP1A2，CYP3A4 和 CYP2C9，IC₅₀ 分别为 58.0±4.5 μM，78.4±5.3 μM，81.7±2.6 μM 和 85.1±9.1 μM。

研究领域：NF-κB  |  Immunology/Inflammation  |  Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：NF-κB  |  COX  |  Calcium Channel  |  Cytochrome P450  |  Endogenous Metabolite

In Vitro: Ginsenoside Rd is one of the most abundant ingredients of Panax ginseng. Ginsenoside Rd significantly inhibits TNF-α-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 in HepG2 cells. Ginsenoside Rd also inhibits expression of COX-2 ａnd iNOS mRNA ａnd iNOS promoter activity in a dose-dependent manner. To determine nontoxic concentrations, HepG2 cells are treated with various concentrations (0.1, 1, ａnd 10 μM) of compounds (e.g., Ginsenoside Rd) ａnd cell viability is measured using an MTS assay. No compounds are significantly cytotoxic at up to 10 μM, indicating that NF-κB inhibition is not due to cell toxicity. Ginsenoside Rd is one of the most abundant ingredients of Panax ginseng, protects the heart via multiple mechanisms including the inhibition of Ca²⁺ influx. Ginsenoside Rd reduces I_Ca,L peak amplitude in a concentration-dependent manner (IC₅₀=32.4±7.1 μM). Ginsenoside Rd exhibits an inhibition against the activity of CYP2D6 in human liver microsomes with an IC₅₀ of 58.0±4.5 μM, a weak inhibition against the activity of CYP1A2, CYP3A4, ａnd CYP2C9 in human liver microsomes with IC₅₀s of 78.4±5.3, 81.7±2.6, ａnd 85.1±9.1, respectively, ａnd an even weaker inhibition against the activity of CYP2A6 in human liver microsomes with an IC₅₀ value of more than 100 μM.

In Vivo: Ginsenosides Rd is a major compound isolated from Gynostemma pentaphyllum that holistically improves gut microenvironment ａnd induces anti-polyposis in Apc^Min/+ mice. Six-weeks-old mice are subjected to Ginsenoside Rd treatment, before the appearance of the intestinal polyps. All the mice are monitored for food intake, water consumption, ａnd weight changes. Throughout the experiment, no Rb3/ Ginsenoside Rd-associated weight loss in mice is observed. In addition, of the treated mice show variations in food ａnd water consumption. Whereas, the number ａnd size of the polyps are effectively reduced by Ginsenoside Rd treatments.

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