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Psoralidin

CAS No. : 18642-23-4

MCE 站：Psoralidin

产品活性：Psoralidin 是 COX-2 和 5-LOX 的双重抑制剂。具有抗癌，抗菌和抗炎作用。Psoralidin 显著下调 NOTCH1 信号传导。Psoralidin 还极大地诱导 ROS 产生。

研究领域：Immunology/Inflammation  |  Metabolic Enzyme/Protease  |  Neuronal Signaling  |  Stem Cell/Wnt  |  NF-κB  |  Anti-infection

作用靶点：COX  |  Lipoxygenase  |  Notch  |  Reactive Oxygen Species  |  Bacterial

In Vitro: Three breast cancer cell (BCC)populations (ALDH^- cells, ALDH⁺ cells, ａnd commercial BSCSs) are sensitive to Psoralidin treatment (10, 15, 20, ａnd 25 μM; 24 hours) with IC₅₀s ranging from 18 to 21 μM; however, the MCF-12A cells were resistant to Psoralidin.
Psoralidin (30 μM; 24 hours) results in a significant induction of apoptosis for ALDH^- cells, ALDH⁺ cells, ａnd commercial BCSCs.
Psoralidin treatment also downregulates NOTCH1 expression in both ALDH^- ａnd ALDH⁺ cells.

In Vivo: Psoralidin (5 mg/kg) regulates expression of pro-inflammatory cytokines that play an important role in inflammatory diseasesin IR-irradiated lung of BALB/c mouse.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  Neuronal Signaling Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Differentiation Inducing Compound Library  |  Lipid Compound Library  |  Oxygen Sensing Compound Library  |  Antibacterial Compound Library  |  Ferroptosis Compound Library  |  Pyroptosis Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Angiogenesis Related Compound Library  |  Mitochondria-Targeted Compound Library  |  Transcription Factor Targeted Library  |  Lipid Metabolism Compound Library   |  Food-Sourced Compound Library   |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Puromycin dihydrochloride  |  Acetylcysteine  |  Dexamethasone  |  Staurosporine  |  H2DCFDA  |  Doxycycline (hyclate)  |  G-418 disulfate  |  Actinomycin D  |  5-Azacytidine  |  Etoposide  |  CCCP  |  DAPT  |  Nigericin sodium salt  |  Mitomycin C  |  Resveratrol  |  Quercetin  |  Mitoqui mesylate  |  Tunicamycin  |  Hygromycin B  |  Tacrolimus  |  Ionomycin  |  Valproic acid  |  Acetaminophen  |  Vancomycin hydrochloride  |  Streptozocin  |  Tanespimycin  |  (-)-Epigallocatechin Gallate  |  L-Ascorbic acid

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