型号:
产品价格:电议      采购度:1589      原产地:美洲
发布时间:2021/11/4 21:08:25 所属地区:国外 国外
简要描述:
Corynoxeine, 从 Maslinic acid 可抑制 NF-κB p65 的 DNA 结合活性, 并消除 IκB-α 磷酸化。
rhynchophylla 的钩中分离的,是 PDGF-BB 诱导血管平滑肌细胞 (VSMCs) 增殖过程中的一种有效 ERK1/ERK 2 抑制剂。
标签:Crategolic acid
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CAS No. : 4373-41-5
MCE 站:Maslinic acid
产品活性:Maslinic acid 可抑制 NF-κB p65 的 DNA 结合活性, 并消除 IκB-α 磷酸化。
研究领域:NF-κB | Anti-infection
In Vitro: Maslinic acid (MA) inhibits LPS-induced NF-κB translocation to nucleus and phosphorylation of IκB-α. Maslinic acid has also been reported to suppress NF-κB regulated osteoclastogenesis in bone marrow monocytes and inhibit TNF-α-induced NF-κB activity and its downstream genes’ expression in pancreatic cancer cells. To confirm if the anti-inflammatory effects of olive pomace extracts (OPEs) inRAW264.7 cells can be attributed to Maslinic acid, dose-dependence experiments determined the effective concentration of Maslinic acid to be 10-20 μM. 20 μM Maslinic acid significantly suppresses TNF-α production and inhibits IL-1, IL-6, and COX-2 mRNA expression in RAW 264.7 cell. Maslinic acid (at 10 and 20 μM) significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells. Pretreatment with Maslinic acid significantly reduces the LPS-induced phosphorylation of IκB-α.
In Vivo: Paw swelling is alleviated when mice are administered with 200 mg/kg Maslinic acid (MA), significantly suppressing inflammation, compared to the carrageenan induced control group, 4 h after λ-carrageenan injection (0.91±0.51 mm and 1.79±0.4 mm, respectively).
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更新时间:2024/1/2 10:18:59
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