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Cucurbit[8]uril

CAS No. : 259886-51-6

MCE 站：Cucurbit[8]uril

产品活性：Cucurbit[8]uril 是一种高效、低毒、具有口服活性的蛋白异二聚化超分子诱导剂。Cucurbit[8]uril 诱导 methylviologen 和 naphthalene 功能化蛋白的异二聚。Cucurbit[8]uril 可诱导能量转移。

研究领域：Others

作用靶点：Others

In Vitro: Cucurbit[8]uril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%.
Cucurbit[8]uril indeed selectively induces the heterodimerization of MV–eYFP with Np–eCFP. Cucurbit[8]uril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbit[8]uril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbit[8]uril with methylviologen (MV) ａnd naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbit[8]uril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces.

In Vivo: Cucurbit[8]uril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice.

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