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MBC-11 triethylamine

CAS No. :

MCE 站：MBC-11 triethylamine

产品活性：MBC-11 triethylamine 是首创的、骨靶向双膦酸乙酯与抗代谢物阿糖胞苷 (araC) 共价结合的偶联物。MBC-11 triethylamine 具有用于肿瘤性骨病 (TIBD) 的潜力。

研究领域：Others

作用靶点：Others

In Vitro: MBC-11 shows similar activity profiles ａnd significantly inhibits growth of all three cell lines between 10^-8 ａnd 10^-4 M. MBC-11 decreases KAS-6/1 cell growth from approximately 56% at 10^-8 M to 6% at 10^-5 M

In Vivo: MBC-11 (0.04 μg/day, s.c.) has a lower incidence of bone metastases of 40% compared to those treated with PBS (90%) or 0.04 μg/day zoledronate (100%). MBC-11 also significantly decreases bone tumor burden compared to PBS- or zoledronate-treated mice.
Weight gained in mice treated with up to 500 μg/day of MBC-11 is similar to the PBS treated group.
These results demonstrate that MBC-11 decreases bone tumor burden, maintains bone structure, ａnd may increase overall survival, warranting further investigation as a treatment for tumor-induced bone disease (TIBD).

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