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SB-747651A

CAS No. : 607372-46-3

MCE 站：SB-747651A

产品活性：SB-747651A 是一种特异性的丝裂原和应激激活激酶1 (MSK1) 抑制剂。SB-747651A 可用于炎症的研究。

研究领域：Others

作用靶点：Others

In Vitro: SB-747651A (5 μM; neutrophils) affects CXCL2-induced intraluminal crawling of neutrophils in a Mac-1-dependent manner. SB-747651A thwarts the intraluminal crawling of adherent neutrophils to optimal sites of emigration. SB-747651A (5 μM; neutrophils) significantly increases transmigration time ａnd detachment time. SB-747651A affects mechanisms that regulate transendothelial migration of neutrophils in response to CXCL2 chemotactic gradient. SB-747651A inhibits the migration speed of extravascular chemotaxing neutrophils but does not affect their directionality in response to CXCL2 chemotactic gradient.

In Vivo: SB747651A (3 mg/kg; intrascrotal injection) results in increased neutrophil adhesion 3.5~4.5 hours following stimulation with CXCL2 as compared to the effect of CXCL2.
SB-747651A (3 mg/kg; i.p.) affects neutrophil extravasation by increasing neutrophil emigration only at 3 ａnd 4 hours in mouse peritonitis model of acute inflammation.

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