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myo-Inositol trispyrophosphate hexasodium

CAS No. : 23103-35-7

MCE 站：myo-Inositol trispyrophosphate hexasodium

产品活性：myo-Inositol trispyrophosphate (ITPP) hexasodium 是血红蛋白 (haemoglobin) 调节剂，是一种变构效应物，可降低血红蛋白的氧结合亲和力并促进红细胞释放氧。myo-Inositol trispyrophosphatehexasodium 可以逆转缺氧，控制肿瘤生长并改善化疗反应。

研究领域：Others

作用靶点：Others

In Vitro: myo-Inositol trispyrophosphate hexasodium (10 mmol/L; 2 hours) significantly inhibits OCR in all six cell lines (FSaII, SiHa, MDA‐MB‐231, NT2, 9L‐glioma ａnd rhabdomyosarcoma) .

In Vivo: myo-Inositol trispyrophosphate hexasodium (2 g/kg weekly; IP; 7weeks) sustains its significant effect on life prolongation.
myo-Inositol trispyrophosphate hexasodium (1.5 g/kg weekly; IV; for 8 weeks) remains metastasis-free on pancreatic carcinomas in immunocompetent male Lewis rats weighing 120-150 g with DSL-6A/C1 cells. myo-Inositol trispyrophosphate hexasodium restores the pO2 pressure in tumors reducing hypoxia-inducible ａnd proangiogenic factors.
myo-Inositol trispyrophosphate hexasodium (2 g/kg; once daily for 2 days) shows the most elevated tumour oxygenation at 2 hours in four mouse tumour models (mouse fibrosarcoma FSaII implanted in C3H mice, mouse mammary tumour NT2 in FVb/Nrj mice, human breast cancer MDA‐MB‐231 in NMRI nude mice ａnd human cervix squamous cell carcinoma SiHa in NMRI nude mice) ａnd two rat tumour models (rat 9L‐glioma in Fischer F344 rats ａnd rat rhabdomyosarcoma in WAG/Rij rats).

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