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Bryonolic acid

CAS No. : 24480-45-3

MCE 站：Bryonolic acid

产品活性：Bryonolic acid 是一种活性三萜化合物，具有免疫调节、抗炎，抗氧化和抗癌等活性。

研究领域：Immunology/Inflammation

作用靶点：NO Synthase

In Vitro: Bryonolic acid exerts anti-allergic activity by inhibiting homologous passive cutaneous anaphylaxis ａnd delayed hypersensitivity. Bryonolic acid reduces nitric oxide by suppressing inducible nitric oxide synthase expression, indicating anti-inflammatory activity.
In rat adrenal pheochromocytoma (PC12) cells, Bryonolic acid against N-methyl-D-aspartate (NMDA)-induced neurotoxicity, indicating it as a candidate neuroprotective agent for cerebral ischemic treatment.
Bryonolic acid (1-200 μM) inhibits acyl-coA: cholesterol acyl transferase (ACAT) activity in rat liver microsomes in a concentration-dependent manner, blocking the biosynthesis of the cholesterol fatty acid ester tumour promoter. Bryonolic acid inhibits ACAT in intact cancer cells with an IC₅₀ of 12.6 µM.
Bryonolic acid inhibits both clonogenicity ａnd invasiveness in MCF-7 MB-231, U87 ａnd 3T3-EA cells.

In Vivo: Bryonolic acid (500 mg/kg; i.p.; once) potently induces HO-1 in a manner dependent on the Nrf2-Keap1 pathway.

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