MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Kazinol B

CAS No. : 99624-27-8

MCE 站：Kazinol B

产品活性：Kazinol B 是一种带有二甲基吡喃环的异戊二烯化黄烷，是一氧化氮 (NO) 生成的抑制剂。Kazinol B 通过胰岛素-Akt 信号通路和 AMPK 激活增强葡萄糖摄取，从而改善胰岛素敏感性。Kazinol B 具有用于糖尿病研究的潜力。

研究领域：Immunology/Inflammation  |  PI3K/Akt/mTOR  |  Epigenetics

作用靶点：NO Synthase  |  Akt  |  AMPK

In Vitro: Kazinol B (2, 10 ａnd 20 μM; 72 hours) shows no toxicity to adipocytes in 3T3-L1 cells.
Kazinol B (2-20 μM; 72 hours) dose-dependently increases lipid accumulation by 2.4-fold (at 20 μM) treatment as compared with MDI-treated cells.
Kazinol B (2-20 μM; 5 days) dose-dependently increases PPARγ ａnd C/EBPα protein ａnd mRNA levels in MDI-treated 3T3-L1 adipocytes. Kazinol B increases the mRNA level of adiponectin in a dose-dependent manner.
Kazinol B (2-20 μM; 24 hours) increases the retained 2ʹNBDG-fluorescence in cells in a dose-dependent manner in differentiated 3T3-L1 adipocytes ａnd C2C12 myoblasts. Kazinol B dependently increases the MDI-stimulated GLUT4 mRNA level up to 4.7-fold as compared with MDI-only treated cells.
Kazinol B (10-20 μM; pre-treated for 1 h followed by 1 h insulin) dose-dependently increases insulin-dependent Akt phosphorylation. Kazinol B alone strongly induces Akt phosphorylation compared with untreated cells. Kazinol B also increased insulin-stimulated AMPK phosphorylation.
Kazinol B (6.25, 12.5, 25, 50 μM; 18 hours) dose-dependently reduces amounts of iNOS protein in macrophages (RAW 264.7 cells) activated by LPS (1 ug/mL).

相关产品：Doxorubicin hydrochloride  |  Dorsomorphin  |  Metformin hydrochloride  |  MK-2206 dihydrochloride  |  AICAR  |  SC79  |  Mifepristone  |  Capivasertib  |  L-NAME hydrochloride  |  Ipatasertib  |  A-769662  |  Honokiol  |  GSK-690693  |  MK8722  |  AKT inhibitor VIII  |  STO-609  |  Artemisinin  |  Bempedoic acid  |  Guggulsterone  |  1400W Dihydrochloride  |  Oridonin  |  Miransertib  |  Recilisib  |  Perifosine  |  Phenformin hydrochloride  |  L-NMMA acetate  |  L-Arginine

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。