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Oenothein B

CAS No. : 104987-36-2

MCE 站：Oenothein B

产品活性：Oenothein B 是一种二聚体大环鞣花单宁，具有广泛的药理活性，包括抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。Oenothein B 是一种有效且特异性的聚 (ADP-核糖) 糖水解酶抑制剂。

研究领域：Anti-infection  |  Apoptosis

作用靶点：HCV  |  Bacterial  |  Apoptosis  |  Fungal

In Vitro: Oenothein B (15-45 µM; 12-72 hours) has a dose- ａnd time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours ａnd 72 hours of exposure.
Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis ａnd arresting cells at G1 stage.
Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax).
A549 cells 15 µM, 30 µM ａnd 45 µM 24 hours Arrested cells in the G1 phase. A549 cells 15 µM, 30 µM ａnd 45 µM 24 hours BAX, p53, cytochrome c (cytoplasm) ａnd PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.

In Vivo: Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice.

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