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Girinimbine

CAS No. : 23095-44-5

MCE 站：Girinimbine

产品活性：Girinimbine (Girinimbin) 是一种咔唑类生物碱，具有多种生物学作用。Girinimbine 可诱导细胞凋亡 (apoptosis)，具有抗锥虫、抗血小板活性、抗菌活性、抗炎、抗氧化和抗肿瘤活性。

研究领域：Apoptosis  |  Anti-infection

作用靶点：Apoptosis  |  Bacterial  |  Parasite

In Vitro: Girinimbine (1-400 µM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 ａnd 72 h with IC₅₀ values of 61 µM, 56 µM, ａnd 40 µM respectively. Girinimbine (10-100 µM; 24-48 h) increase of LDH leakage in both concentration- ａnd time-dependent manner in HepG2 cells.
Girinimbine (56 µM; 24-48 h) treatment results in DNA fragmentation ａnd elevates levels of caspase-3 in HepG2 cells. HepG2 cells.
Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) ａnd caused G0/G1-phase arrest.
Girinimbine shows a potent antitrypanosomal activitywith an IC₅₀ value of 10.16 µg/mL.

In Vivo: Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, ａnd reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid.
In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos.

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