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WAY-262611

CAS No. : 1123231-07-1

MCE 站：WAY-262611

产品活性：WAY-262611是 Wnt/β- 联蛋白激动剂，可增加骨形成速率，在 TCF- 荧光素酶测定实验中的 EC₅₀ 值为0.63 μM。WAY-262611 也是 Dkk1 的抑制剂。

研究领域：Stem Cell/Wnt

作用靶点：β-catenin

In Vitro: WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, ａnd high solubility.

In Vivo: WAY-262611 has excellent pharmacokinetic properties ａnd shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β-catenin pathway ａnd most likely through inhibition of Dkk-1.

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