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SB-3CT

CAS No. : 292605-14-2

MCE 站：SB-3CT

产品活性：SB-3CT 是一种有效竞争型的金属蛋白酶 MMP-2 和 MMP-9 抑制剂，K_i 值分别为 13.9 nM、600 nM。SB-3CT 对明胶酶具有高选择性。SB-3CT 可透过血脑屏障，具有神经保护和抗癌作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：MMP

In Vitro: SB-3CT has shown efficacy in an animal model of severe traumatic brain injury (TBI). SB-3CT inhibits MMP-9 with an inhibition constant K_i of 400±15 nM.
Inhibition of PC3 tumor growth by SB-3CT could also be a direct consequence of reduced extracellular matrix degradation within the bone tissue by the tumor cells themselves and/or by osteoclasts. Indeed, SB-3CT treatment is associated with a reduced osteolytic response, indicating that SB-3CT helps to preserve bone integrity.

In Vivo: SB-3CT (i.p.; 50 mg/kg; every other day; five weeks) inhibits intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice.

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