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SLC13A5-IN-1

CAS No. : 2227548-95-8

MCE 站：SLC13A5-IN-1

产品活性：SLC13A5-IN-1 是一种选择性柠檬酸钠协同转运蛋白 (SLC13A5) 抑制剂。SLC13A5-IN-1 完全阻断 HepG2 细胞摄取 ¹⁴C-柠檬酸，IC₅₀ 值为 0.022 μM。SLC13A5-IN-1 可以用于研究代谢和/或心血管疾病的研究。SLC13A5-IN-1 源于 WO2018104220A1，化合物 I-5。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Sodium Channel

In Vitro: SLC13A5-IN-1 exhibits an IC₅₀ of 0.022 μM in HepG2/¹⁴C-Citrate Uptake Assay. HepG2 cells endogenously express hSLC13A5 transporter which is responsible for the uptake of citrate into these cells. Uptake of ¹⁴C-citrate can be completely blocked by SLC13A5-IN-1 ａnd the signal can be competed with unlabelled citrate. T.
SLC13A5-IN-1 exhibits an IC₅₀ of 0.056 μM in recombinant hSLC3A5/¹⁴C-Citrate Uptake Assay.
SLC13A5-IN-1 exhibits an IC₅₀ of 100 μM in recombinant Human GlyT2/3H-Glycine Uptake Assay. The human embryonic kidney 293 cells are used that stably over-express the human GlyT2 receptor which is responsible for the uptake of glycine into these cells. Uptake of 3H-glycine can be completely blocked by SLC13A5-IN-1.

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