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DIPPA hydrochloride

CAS No. : 155512-52-0

MCE 站：DIPPA hydrochloride

产品活性：DIPPA (hydrochloride) 是一种不可逆、长效、选择性和高亲和力的 κ-opioid receptor 拮抗剂。DIPPA (hydrochloride)可用于焦虑和抗抑郁药物的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Opioid Receptor

In Vivo: DIPPA (2.5 ａnd 5 mg/kg; s.c.) hydrochloride decreases the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats.
DIPPA (1 ａnd 5 mg/kg; s.c.) hydrochloride high dose increases immobility in SD rats compared to the saline-treated strain control group.
DIPPA (5 mg/kg) hydrochloride decreases consumption in SD rats compared to the 5 mg/kg group of Wistar Kyoto rats. DIPPA hydrochloride significantly decreases burying time in both strains. DIPPA (5 mg/kg) hydrochloride decreases burying in both strains compared to the within strain control groups. DIPPA hydrochloride tends to decrease consumption in SD rats in the home cage but significantly increases feeding in the novel cage where potential anxiolytic-like effects of DIPPA hydrochloride may oppose the hypophagic effects of the compound.

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