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产品价格:电议      采购度:1625      原产地:美洲
发布时间:2021/11/30 21:35:54 所属地区:国外 国外
简要描述:
(S)-Selisistat ((S)-EX-527) 是一种有效,选择性的 SIRT1 抑制剂,IC50 值为 98 nM。
标签:(S)-EX-527
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CAS No. : 848193-68-0
MCE 站:(S)-Selisistat
产品活性:(S)-Selisistat ((S)-EX-527) 是一种有效,选择性的 SIRT1 抑制剂,IC50 值为 98 nM。
研究领域:Cell Cycle/DNA Damage | Epigenetics
作用靶点:Sirtuin
In Vitro: (S)-Selisistat is an inhibitor of SIRT1 enzymatic activity (IC50, 98 nM), identified in a high-throughput screen using bacterially expressed human SIRT1. (S)-Selisistat inhibits SIRT1 in a concentration-dependent manner with an IC50 of 38 nM, in agreement with the activity on bacterially expressed SIRT1. (S)-Selisistat has much lower potency against SIRT2 (IC50, 19.6 μM) or SIRT3 (IC50, 48.7 μM) but does not inhibit class I/II HDAC activity at concentrations up to 100 μM. (S)-Selisistat exerts an inhibitory effect on SIRT1 activity without affecting SIRT1 expression on both mRNA and protein levels.
In Vivo: (S)-Selisistat abolishes Resveratrol (RSV)-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group has significantly increased 7-day survival vs. Sepsis+Vehicle group.
相关产品:Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Glutamine Metabolism Compound Library | Resveratrol | Selisistat | Nicotinamide | Nicotinamide riboside chloride | 3-TYP | Suramin sodium salt | Fisetin | OSS_128167 | SRT 1720 Hydrochloride | SRT 2104 | UBCS039 | Sirtinol | AGK2 | Thiomyristoyl | CAY10602 | SIRT5 inhibitor 1 | SIRT7 inhibitor 97491 | Tenovin-6 | MC3482 | Cambinol | AK-7 | AK-1 | SRT 2183 | Ganoderic acid D | Ginkgolide C | PROTAC Sirt2 Degrader-1 | SIRT-IN-3 | Dihydrocoumarin | Gardenia yellow
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更新时间:2024/1/2 10:19:40
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