MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

WZ4003

CAS No. : 1214265-58-3

MCE 站：WZ4003

产品活性：WZ4003 是一种有效的，高度特异性的 NUAK kinase 抑制剂，能够抑制 NUAK1 (ARK5)/NUAK2 的活性，IC₅₀ 值分别为 20 nM/100 nM。

研究领域：Epigenetics  |  PI3K/Akt/mTOR

作用靶点：AMPK

In Vitro: WZ4003 (3-10 μM) markedly suppresses NUAK1-mediated MYPT1 phosphorylation, in HEK-293 cells expressing wild-type NUAK1. Moreover, WZ4003 (10 μM) inhibits MYPT1 Ser445 phosphorylation as well as cell migration, invasion ａnd proliferation to a similar extent as knock out in MEFs or knock down in U2OS cells of NUAK1. WZ4003 also exhibits a high, specific affinity to the L858R/T790M mutant EGFR, while a significantly reduced cellular IC₅₀ against T790M containing Ba/F3 cells.

相关产品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Lipid Metabolism Compound Library   |  Glucose Metabolism Compound Library  |  Doxorubicin hydrochloride  |  Dorsomorphin  |  Metformin hydrochloride  |  AICAR  |  A-769662  |  GSK-690693  |  MK8722  |  STO-609  |  Bempedoic acid  |  Phenformin hydrochloride  |  [6]-Gingerol  |  EX229  |  HTH-01-015  |  Flufenamic acid  |  PF-06409577  |  GSK621  |  MK-3903  |  Urolithin B  |  Palmitelaidic Acid  |  ON123300  |  Chitosan oligosaccharide  |  O-304  |  Amarogentin  |  MRT199665  |  Buformin hydrochloride  |  EB-3D  |  Platycodin D

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。