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DMH-1

CAS No. : 1206711-16-1

MCE 站：DMH-1

产品活性：DMH-1 是一种有效的，具有选择性的 BMP 抑制剂，对 ALK1/ALK2/ALK3/ALK6的IC₅₀ 值分别为 27/107.9/<5/47.6 nM。

研究领域：Autophagy  |  TGF-beta/Smad

作用靶点：Autophagy  |  TGF-β Receptor

In Vitro: DMH-1 (0.5 μM) induces regulation of OCT4, Nanog, ａnd PAX6 protein expression. DMH-1 significantly reduces the percentage of cells expressing the pluripotency marker proteins OCT4 ａnd Nanog in both SM3 ａnd CA6 cells. PAX6 expression is significantly up-regulated by day 5 ａnd day 7 in CA6 ａnd SM3 cells, respectively. DMH-1 induces regulation of pluripotency ａnd neural precursor marker mRNAs. PAX6 can regulate the expression of SOX1 independently by manipulating the DMH-1 concentration during the neural induction of hiPSCs. DMH-1 (5 μM ａnd 10 μM) inhibits CDDP-induced autophagy in HeLa cells ａnd enhances the ability of CDDP to reduce HeLa cell viability, inhibits tamoxifen-induced autophagy in MCF-7 cells ａnd enhances the ability of tamoxifen to reduce MCF-7 cell viability, inhibits 5-FU-induced autophagy in both MCF-7 ａnd HeLa cells but does not affect the inhibitory effects of 5-FU on MCF-7 ａnd HeLa cell viability. DMH-1 enhances the apoptotic induction effects of CDDP on HeLa cells after 24 h treatment. DMH-1 inhibits HeLa ａnd MCF-7 cell proliferation. DMH-1 (20 μM) reduces the canonical phosphorylation of Smads 1,5 ａnd 9. DMH-1 in combination with Cisplatin significantly decreases Ki-67 positive staining in the OVCAR8 cells. DMH-1 (20 µM) upregulates JAG1, reduces CYP1B1 ａnd increases HAPLN1 expression in both OVCAR8 ａnd NCI-RES cells.

In Vivo: DMH1 (5 mg/kg, i.p.) treatment significantly reduces the tumor growth in human lung cancer xenograft model.

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