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BW-180C

CAS No. : 63631-40-3

MCE 站：BW-180C

产品活性：BW-180C ([D-Ala2, D-Leu5]-Enkephalin) 是水溶性的多肽类阿片受体 (Opioid Receptor) 激动剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Opioid Receptor

In Vitro: BW-180C ([D-Ala2, D-Leu5]-Enkephalin) significantly inhibits cellular transcription in SH-SY5Y cells without causing cell injury. Following recovery for 72 h without BW-180C in primary neurons, the transcriptional activity fully resumes.

In Vivo: BW-180C ([D-Ala2, D-Leu5]-Enkephalin) protects against I-R injury in hepatocytes, but not in the sinusoidal endothelial cells of the liver in rats. GPT levels are significantly lower in the BW-180C group as compared to those of the Control group, but the serum levels of HA are not different between the two groups. The concentrations of MDA of the liver tissue are significantly lower in the BW-180C group than in the Control group. BW-180C (DADLE)-induced analgesia is mediated by the stimulation of both mu- ａnd delta-opioid receptors.

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