MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ladostigil hemitartrate

CAS No. : 209394-46-7

MCE 站：Ladostigil hemitartrate

产品活性：Ladostigil (TV-3326) hemitartrate 是胆碱酯酶 (cholinesterase) 和脑选择性单胺氧化酶 (MAO) 的双重抑制剂，抑制 MAO-B 和 AChE 的 IC₅₀ 值分别为 37.1 和 31.8 μM。Ladostigil hemitartrate 具有神经保护，抗氧化和抗炎作用，可用于抑郁症，阿尔茨海默症和帕金森氏症的研究。

研究领域：Neuronal Signaling

作用靶点：Monoamine Oxidase  |  AChE

In Vitro: Ladostigil (1-10 ?M) hemitartrate exerts neuroprotective activities, including a prevention of the fall of the mitochondrial membrane potential (ψ), attenuation of apoptotic cascades and an inhibition of ROS production induced by OS insults.
Ladostigil (1-10 ?M) hemitartrate has a significant neuroprotective activity, including inhibition of caspase-3 activation, induction of Bcl-2 and reduction of Bad and Bax gene and protein expression in human neuroblastoma SK-N-SH cells.

In Vivo: Ladostigil (17 mg/kg; p.o. daily for 6 weeks) hemitartrate abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats.
Ladostigil (50 μmol/kg; single p.o.) hemitartrate restores the loss of episodic memory in the object recognition test in rats.

相关产品：Bioactive Compound Library Plus  |  Neuronal Signaling Compound Library  |  Reprogramming Compound Library  |  Anti-Alzheimer's Disease Compound Library  |  Neuroprotective Compound Library  |  Anti-Parkinson's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Mitochondria-Targeted Compound Library  |  β-Aminopropionitrile  |  Rosmarinic acid  |  Donepezil Hydrochloride  |  Clorgyline hydrochloride  |  GSK-LSD1 dihydrochloride  |  Methylene Blue  |  Paeonol  |  Tranylcypromine hemisulfate  |  Garcinol  |  Galanthamine  |  PXS-5153A monohydrochloride  |  Rivastigmine  |  (2-Chloropyridin-4-yl)methanamine hydrochloride  |  Phenelzine sulfate  |  sn-Glycero-3-phosphocholine  |  Coumaran  |  Rasagiline mesylate  |  PAT-1251  |  Pargyline hydrochloride  |  Pyridostigmine bromide  |  Physostigmine salicylate  |  Safinamide  |  Scopoletin  |  Protriptyline hydrochloride  |  α-NETA  |  (-)-Huperzine A  |  CCT365623 hydrochloride  |  Imperatorin  |  J-147

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。