MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

SB-277011 hydrochloride

CAS No. : 215804-67-4

MCE 站：SB-277011 hydrochloride

产品活性：SB-277011 hydrochloride (SB-277011A hydrochloride) 是一种强效、选择性、口服生物利用度和脑透多巴胺 D₃ 受体(D₃R) 拮抗剂，其 K_i 值在啮齿动物和人D₃R 分别为 10.7 nM 和 11.2 nM。SB-277011 hydrochloride 对 D3 受体比其他多巴胺受体表现出 80-100 倍的选择性，，对 D₃，D₂，5-HT_1B?和 5-HT_1D 受体的?pK_i 值分别为 8.0，6.0，<5.2 和 5.9。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor  |  5-HT Receptor

In Vivo: SB-277011 hydrochloride has an excellent pharmacokinetic profile, exhibits oral bioavailability 43%, half-life:2.0 h, plasma clearance 19 mL/min/kg) and to be highly brain-penetrant (brain:blood ratio of 3.6:1), with a clean P450 profile in the rat.
SB-277011 hydrochloride (SB 277011; 3 mg/kg, p.o.) completely reverses the effects of quinelorane in the nucleus accumbens, but does not reverse the effects of quinelorane in the striatum at 93 mg/kg in rats.
SB-277011 (intraperitoneal injection; 12.5-25 mg/kg) significantly and dose-dependently reduces intravenous cocaine self-administration under both low fixed-ratio and progressive-ratio reinforcement conditions in rats. When it increases to 50 mg/kg, SB-277011 can significantly inhibit basal and cocaine-enhanced locomotion in rats.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Neurotransmitter Receptor Compound Library  |  Anti-Alzheimer's Disease Compound Library  |  Anti-Parkinson's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Targeted Diversity Library  |  Clozapine N-oxide  |  MPTP hydrochloride  |  Oxidopamine hydrobromide  |  Chlorpromazine hydrochloride  |  Serotonin hydrochloride  |  Harmine  |  L-DOPA  |  Puerarin  |  Bromocriptine mesylate  |  Pimozide  |  SCH-23390 hydrochloride  |  Haloperidol  |  GTS-21 dihydrochloride  |  Dihydroergotamine mesylate  |  Cabergoline  |  SKF 38393 hydrochloride  |  SB-269970 hydrochloride  |  Risperidone  |  Ketanserin  |  Thioridazine hydrochloride  |  Aripiprazole  |  WAY-100635 Maleate  |  Amitriptyline hydrochloride  |  Buspirone hydrochloride  |  Brexpiprazole  |  Pimavanserin  |  Cisapride  |  Quetiapine

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。