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Terrein

CAS No. : 582-46-7

MCE 站：Terrein

产品活性：Terrein 是一种黑色素生成抑制剂。Terrein 诱导乳腺癌细胞凋亡 (apoptosis)。Terrein是铜绿假单胞菌 (Pseudomonas aeruginosa) 中的群体感应和 c-di-GMP 抑制剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Apoptosis  |  Anti-infection

作用靶点：Melanocortin Receptor  |  Apoptosis  |  Antibiotic

In Vitro: Treatment of Mel-Ab cells with Terrein (10-100 ?M) for 4 days significantly reduces melanin levels in a dose-dependent manner. Terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation.
Terrein (5-500 ?M; 24 and 48 hours) reduces the viability of these cells in concentration- and time-dependent manners.
Terrein (150, 250, 500?M; 24 hours) induces programmed cell death in both invasive and non-invasive breast cancer cell lines. Thus, the optimal non-toxic concentrations of Terrein (25 and 75 ?M) were used for subsequent experiments.
Terrein (25 and 75 ?M) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MDA-MB-231 cells. Terrein (75 ?M) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MCF-7 cells.
Terrein (75 ?M) inhibits the expression of RhoA, RhoB, p-Rac1 in MCF-7 cells. Terrein (75 ?M) inhibits the expression of RhoB, p-Rac1 in MDA-MB-231 cells.
Terrein (10, 30, and 100?μM) inhibits the production of virulence factors such as elastase, pyocyanin, and rhamnolipid, as well as biofilm formation in P. aeruginosa PAO1 and PA14 strains.

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