MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

NGB 2904

CAS No. : 189060-98-8

MCE 站：NGB 2904

产品活性：NGB 2904 是一种具有口服活性和选择性的多巴胺(DA) D₃受体拮抗剂。NGB 2904 可用于可卡因成瘾的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor

In Vivo: NGB 2904 (0.1~5 mg/kg; i.p.) significantly loweres the break-point for cocaine self-administration behavior reinforced under progressive-ratio conditions and significantly inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats extinguished from daily cocaine self-administration.
NGB 2904 (0~10 mg/kg; i.p.) administered 30 min prior to the beginning of daily cocaine self-administration sessions has no significant effect on cocaine self-administration behavior at a unit cocaine reinforcement dose of 0.5 mg/kg/infusion compared to vehicle-treated animals. NGB 2904 (0.1 and 1 mg/kg) pretreatment significantly inhibits the enhanced brain stimulation reward produced by 2 mg/kg, but not by 10 mg/kg, of cocaine. NGB 2904 pretreatment produces a significant attenuation of this cocaine-triggered reinstatement of drug-seeking.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Targeted Diversity Library  |  Clozapine N-oxide  |  MPTP hydrochloride  |  Oxidopamine hydrobromide  |  Chlorpromazine hydrochloride  |  L-DOPA  |  Bromocriptine mesylate  |  Pimozide  |  SCH-23390 hydrochloride  |  Haloperidol  |  Cabergoline  |  SKF 38393 hydrochloride  |  Risperidone  |  Thioridazine hydrochloride  |  WAY-100635 Maleate  |  Brexpiprazole  |  Quetiapine  |  Sulpiride  |  Fluphenazine dihydrochloride  |  Lurasidone  |  Lumateperone tosylate  |  Domperidone  |  ONC206  |  Quinpirole Hydrochloride  |  Clomipramine hydrochloride  |  Sumanirole maleate  |  Perphenazine  |  Levomepromazine  |  Sertindole

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。