MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Withanone

CAS No. : 27570-38-3

MCE 站：Withanone

产品活性：Withanone 是来自 Withania somnifera 根的活性成分，在减轻认知功能障碍方面具有多功能的神经保护作用。在神经元样细胞中，Withanone 可以抑制 NMDA 诱导的兴奋性毒性。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

In Vitro: Withanone (5-20 μM; Neuro2a cells) treatment significantly reverses the cell death induced by NMDA in N2a cells.
Withanone (5-20 μM; Neuro2a cells) treatment significantly normalizes Bax and Bcl-2 levels.
Attenuation of NMDA-induced intracellular calcium releases by Withanone in N2a cells.
Withanone attenuates NMDA-induced Reactive Oxygen Species generation in N2a cells and induces attenuation of mitochondrial membrane motential loss.
Withanone treatment down-regulates the expression of cytochrome c.
Withanone treatment decteases the Malondialdehyde levels in NMDA-induced excitotoxicity.
Withanone shows promise in Alzheimer's disease (AD) treatment because of cognitive benefits and more importantly, mechanisms of action with respect to the fundamental pathophysiology of the disease, not limited to the inhibition of AChE, but also include the modification of Aβ processing, protection against oxidative stress and anti-inflammatory effects. Withanone (24 hours) treatment shows significant protective effect against amyloid β (Aβ) toxicity in Aβ induced toxicity in PC-12 cells.

In Vivo: Withanone (5-20 mg/kg; oral administration; daily; for 21 days; male Wistar rats) treatment shows significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuates the elevated levels of pro-inflammatory cytokines like TNF α, IL-1β, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity. Administration of Withanone also significantly reverses the decline in acetyl choline and Glutathione (GSH) activity.

相关产品：D-AP5  |  Dizocilpine maleate  |  NMDA  |  CNQX  |  NBQX  |  L-Phenylalanine  |  Ibotenic acid  |  Kynurenic acid  |  L-Glutamic acid  |  Glycine  |  Quinolinic acid  |  Cycloleucine  |  Ifenprodil tartrate  |  Memantine hydrochloride  |  D-Cycloserine  |  DNQX  |  Ro 25-6981 Maleate  |  Transcrocetin  |  Tat-NR2B9c TFA  |  PEAQX tetrasodium hydrate  |  Topiramate  |  Traxoprodil  |  CX546  |  LY3130481  |  ZL006  |  Flupirtine Maleate  |  MDL-29951  |  (-)-Huperzine A  |  24-Hydroxycholesterol

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。