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13-Methyltetradecanoic acid

CAS No. : 2485-71-4

MCE 站：13-Methyltetradecanoic acid

产品活性：13-Methyltetradecanoic acid (13-MTD)，一种具有强效抗癌作用的饱和支链脂肪酸。13-Methyltetradecanoic acid 在多种类型的人类癌细胞中诱导细胞凋亡 (apoptosis)。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: 13-Methyltetradecanoic acid (13-MTD; 0-140 μg/mL; 12-24 hours) inhibits cell viability and proliferation in human bladder cancer cells by inducing apoptosis.
13-Methyltetradecanoic acid (13-MTD; 70 μg/mL; 2-48 hours) treatments results in significant accumulation of cells with sub-G1 DNA content in a time-dependent manner, with the proportion of sub-G1 phase DNA content ranging from 9.25% to 85.3% over 2-48 hours.
13-Methyltetradecanoic acid (13-MTD; 70 μg/mL; 2-24 hours) down-regulates Bcl-2 and up-regulates Bax. This promotes mitochondrial dysfunction, leading to the release of cytochrome c from the mitochondria to the cytoplasm, as well as the proteolytic activation of caspases. 13-Methyltetradecanoic acid down-regulates AKT phosphorylation and activates phosphorylation of p38 and c-Jun N-terminal kinase (JNK).

In Vivo: 13-Methyltetradecanoic acid (13-MTD; 70 mg/kg/day; oral gavage; daily; for 30 days) significantly suppresses tumor growth in a xenograft model.

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