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Urolithin C

CAS No. : 165393-06-6

MCE 站：Urolithin C

产品活性：Urolithin C， 是鞣花酸的多酚类肠道微生物代谢产物，是胰岛素分泌 (insulin secretion) 的葡萄糖依赖性激活剂。Urolithin C 是一种 L 型 Ca²⁺ 通道开放剂，可增强 Ca²⁺ 的流入。Urolithin C 通过线粒体介导的途径诱导细胞凋亡 (apoptosis)，并刺激活性氧 (ROS) 的形成。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Calcium Channel  |  Reactive Oxygen Species  |  Apoptosis  |  Endogenous Metabolite

In Vitro: Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells.
Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis.
Urolithin C treatment induces apoptosis and S phase cell cycle arrest.

In Vivo: The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V₁/F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively.

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