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Metoclopramide hydrochloride hydrate

CAS No. : 54143-57-6

MCE 站：Metoclopramide hydrochloride hydrate

产品活性：Metoclopramide hydrochloride hydrate 是一种有效的 5-HT₃ 和多巴胺 D2 受体拮抗剂，IC₅₀ 值分别为 308 nM 和 483 nM。Metoclopramide hydrochloride hydrate 可用于恶心呕吐、胃食管反流和胃轻瘫的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor  |  Dopamine Receptor

In Vitro: Metoclopramide (0.01-10 μM) hydrochloride hydrate stimulates aldosterone release in isolated perfused rat zona glomerulosa cells.
Metoclopramide hydrochloride hydrate results in prokinesis by four mechanisms: inhibition of presynaptic D2 receptors and stimulation of presynaptic excitatory 5-HT4 receptors, thereby allowing acetylcholine (ACh) release from intrinsic cholinergic motor neurons; inhibition of D2 postsynaptic receptors; and antagonism of the presynaptic inhibition of muscarinic receptors, leading to further augmentation of ACh release.

In Vivo: Metoclopramide (6.7 ?g/g; s.c. daily for 50 days) hydrochloride hydrate significantly increases the number and the volume of lactotroph cells of the pituitary gland during all phases of the estrous cycle.
Metoclopramide (5-40 mg/kg; i.p.) hydrochloride hydrate induces catalepsy and antagonizes Apomorphine induced cage climbing behaviour in mice.
Metoclopramide (1.25-2.5 mg/kg; i.p.) hydrochloride hydrate induces stereotyped cage climbing behaviour in mice.

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