MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Pentosan Polysulfate Sodium (W/W 43%)

CAS No. : 140207-93-8

MCE 站：Pentosan Polysulfate Sodium (W/W 43%)

产品活性：Pentosan Polysulfate Sodium 是一种口服生物可利用的半合成药物，具有抗炎和促软骨生成的特性。Pentosan Polysulfate Sodium 也是一种有效和选择性的抗 HIV 药物。Pentosan Polysulfate Sodium 用于间质性膀胱炎的研究。

研究领域：Anti-infection

作用靶点：HIV

In Vitro: Pentosan Polysulfate Sodium has been shown to inhibit HIV-1 activity with an ED₅₀ of 0.19 μg/mL in MT-4 cells. It inhibits HIV-1 antigen expression in HUT-78 cells at an ED₅₀ of 0.02 μg/mL, and complete inhibition of HIV-1 antigen expression is obtained at a concentration of 4.0 μg/mL.
Pentosan Polysulfate Sodium suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production.

In Vivo: Pentosan Polysulfate Sodium has been shown to decreases interstitial inflammation and glomerulosclerosis in 5/6 nephrectomized rats. Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan Polysulfate Sodium also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  Doxorubicin hydrochloride  |  Chloroquine  |  5-Fluorouracil  |  Q-VD-OPh  |  Panobinostat  |  Valproic acid  |  (-)-Epigallocatechin Gallate  |  Birinapant  |  Plerixafor  |  Shikonin  |  Kaempferol  |  Maraviroc  |  Ivermectin  |  Ebselen  |  Dimethyl fumarate  |  Hydroxyurea  |  Probenecid  |  Baicalin  |  Flavopiridol  |  Ritonavir  |  ABBV-744  |  Betulinic acid  |  Lopinavir  |  Fasudil Hydrochloride  |  Rolipram  |  Oltipraz  |  Lamivudine  |  ONX-0914

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。