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Anisodamine hydrobromide

CAS No. : 55449-49-5

MCE 站：Anisodamine hydrobromide

产品活性：Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide)，颠茄生物碱，也是一种非亚型的选择性毒蕈碱 (muscarinic) 和烟碱类胆碱受体 (nicotinic cholinoceptor) 拮抗剂。Anisodamine hydrobromide 具有抗氧化、抗炎活性。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mAChR

In Vitro: Anisodamine hydrobromide (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuated average fluorescence intensity of α-bungarotoxin binding compared with Ach alone.
Anisodamine hydrobromide action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR.

In Vivo: Anisodamine hydrobromide (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%.

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