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M50054

CAS No. : 54135-60-3

MCE 站：M50054

产品活性：M50054 是一种有效的细胞凋亡 (apoptosis) 抑制剂。M50054 抑制 Etoposide 诱导的 U937 细胞 caspase-3 活化，IC₅₀ 为 79 μg/mL。M50054 不直接抑制 caspase-3 酶活性。M50054可用于研究抗 Fas 抗体引起的肝炎和化疗引起的脱发。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: M50054 inhibits the caspase-3 activation by Etoposide in a dose-dependent manner. The IC₅₀ value of M50054 against Etoposide-induced caspase-3 activation of U937 cells is 79 μg/mL. However, M50054 does not directly inhibit the enzymatic activity of caspase-3 at all concentrations up to 1000 μg/mL.
M50054 (1-300 μg/mL) inhibits soluble human Fas ligand-induced cell death of human Fas-expressing WC8 cells in a dose-dependent manner, ａnd the IC₅₀ of 67 μg/mL.
M50054 (30-300 μg/mL) inhibits the death of U937 cells induced by etoposide (10 μg/mL) in a dose-dependent manner, ａnd the IC₅₀ value of M50054 against Etoposide-induced cell death of U937 cells is 130 μg/mL. The IC₅₀ value of M50054 against etoposide-induced DNA fragmentation of U937 cells was 54 μg/mL.

In Vivo: M50054 (10-300 mg/kg; oral administration 30 min before anti-Fas antibody injection) inhibits the elevation of alanine aminotransferase ａnd aspartate aminotransferase in a dose-dependent manner.
M50054 (topical treatment; given daily beginning on day 5 after birth ａnd ending on day 14) significantly improves alopecia (hair loss) symptoms.

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