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产品价格:电议      采购度:1295      原产地:美洲
发布时间:2022/3/3 20:14:42 所属地区:国外 国外
简要描述:
PHA 568487 free base 是一种选择性的 α 7 烟碱乙酰胆碱受体 (α-7 nAchR) 激动剂。PHA 568487 free base 可用于减缓神经炎症。
标签:pha
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CAS No. : 527680-56-4
MCE 站:PHA 568487 free base
产品活性:PHA 568487 free base 是一种选择性的 α 7 烟碱乙酰胆碱受体 (α-7 nAchR) 激动剂。PHA 568487 free base 可用于减缓神经炎症。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:nAChR
In Vitro: PHA 568487, α-7 nAchR-specific agonist, prevents NF-κb activation in the cells.
PHA 568487 treatment significantly reduces the expression of leukocyte infiltration molecules in MCAO rats and in endothelial cells after in vitro ischemia.
In Vivo: PHA 568487 treatment reduces mouse cognitive decline caused by aseptic bone fracture by promoting inflammation resolution. PHA 568487 (PHA; 0.8 mg/kg; injected intraperitoneally) reduces infarct volume and TUNEL positive neurons in the peri-infarct regions of permanent middle cerebral artery occlusion (pMCAO) and pMCAO+tibia fracture mice.
The role played by a7 receptors on neuroinflammation is supported by the decrease of [18F]DPA-714 binding in ischemic rats treated with the a7 agonist PHA 568487 at day 7 after MCAO.
PHA 568487-treated ischemic rats show a significant reduction of the cerebral infarct volumes and an improvement of the neurologic outcome compared with non-treated MCAO rats.
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更新时间:2024/1/2 10:21:59
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