MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Verrucarin J

CAS No. : 4643-58-7

MCE 站：Verrucarin J

产品活性：Verrucarin J (Muconomycin B) 是 Myrothecium 真菌家族的代谢物。Verrucarin J 诱导活性氧 (ROS) 生成和癌细胞系凋亡 (apoptosis)，例如 A549、HCT 116 和 SW-620 细胞。Verrucarin J 具有抗 Candida albicans 和 Mucor miehei 的活性。Verrucarin J 抑制沙粒病毒 Junin (JUNV) 产量，IC₅₀ 为 1.2 ng/mL。

研究领域：Apoptosis  |  Anti-infection  |  Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Apoptosis  |  Arenavirus  |  Fungal  |  Antibiotic  |  Reactive Oxygen Species

In Vitro: Verrucarin J (0, 5, 10, 20, 50 nM; 24 hours) induces the apoptosis of A549 cells.
Verrucarin J (0, 1, 2, 5, 10, 20, 50 nM; 24, 48, 72 hours) significantly inhibits cell proliferation of A549 ａnd H1793 cells with IC₅₀ values of approximately 10 nM ａnd 20 nM after 48 h of treatment, respectively.
Verrucarin J (0, 0.1, 0.2, 0.3, 0.4, 0.5 μM; 24 hours) has an IC₅₀ of 300 nM for HCT 116 ａnd SW-620 cell proliferation.
Verrucarin J (0, 10, 20 nM, 48 hours) inhibits cancer stem cell (CSC) self-renewal pathways Wnt1/β-catenin ａnd Notch1 ａnd down-regulates the expression of key CSC specific genes (ALDH1, LGR5, OCT4 ａnd CD133) of A549 cells.
Verrucarin J (compound 2; 50 μg/disk) shows noteworthy activities against Candida albicans ａnd Mucor miehei.
Verrucarin J reduces JUNV yield more than 2 log units ａnd has a similar effect against the arenavirus Tacaribe.
Verrucarin J reduces the cell viability of Vero cells with a cytotoxic concentration 50% (CC₅₀) of 8.2 ng/mL.

In Vivo: Verrucarin J (0.5mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model.
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug ａnd suppresses tumor growth ａnd metastasis.

相关产品：MG-132  |  Rapamycin  |  Ferrostatin-1  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Chloroquine  |  Y-27632 dihydrochloride  |  Puromycin dihydrochloride  |  Paclitaxel  |  Cycloheximide  |  Acetylcysteine  |  Angiotensin II human  |  Dexamethasone  |  Staurosporine  |  Tamoxifen  |  5-Fluorouracil  |  Bortezomib  |  2-Deoxy-D-glucose  |  Sorafenib  |  H2DCFDA  |  Trametinib  |  SP600125  |  Gemcitabine  |  Temozolomide  |  G-418 disulfate  |  Doxycycline (hyclate)  |  Verteporfin  |  Decitabine

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。