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S-Allylmercaptocysteine

CAS No. : 2281-22-3

MCE 站：S-Allylmercaptocysteine

产品活性：S-allylmercaptocysteine 是一种从大蒜中提取的有机硫化合物，对各种肺部疾病具有抗炎和抗氧化作用。S-allylmercaptocysteine 通过多种途径发挥抗癌作用，如通过 TGF-β 信号通路诱导癌细胞凋亡 (apoptosis)，或通过降低 NF-κb 活性和上调 Nrf2 来达到抗炎和抗氧化的作用。

研究领域：Apoptosis  |  NF-κB

作用靶点：Apoptosis  |  NF-κB  |  Keap1-Nrf2

In Vitro: S-Allylmercaptocysteine attenuates cisplatin-induced nephrotoxicity through suppression of apoptosis, oxidative stress, ａnd inflammation.
S-Allylmercaptocysteine (400 μM; 48 hours) induces apoptosis evaluated by detecting the activated caspase 3 ａnd cleaved PARP in SW620, SW480, ａnd Caco-2 cells. Both activated caspase 3 ａnd cleaved PARP1 are found in the cells treated with SAMC while no activated PARP1 ａnd caspase 3 are found in the untreated control cells.

In Vivo: S-Allylmercaptocysteine (25 ａnd 50 mg/kg; oral gavage) could significantly ameliorate the pathological structure, ａnd decrease inflammatory cell infiltration ａnd pro-inflammatory cytokines in bronchoalveolar lavage fluid (BALF) in BLM-induced pulmonary fibrosis mice. S-Allylmercaptocysteine shows an anti-fibrosis effect by increasing anti-oxidants like HO-1, GSH ａnd SOD as well as decreasing hydroxyproline (HYP) in BLM-induced mice.

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