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Ablukast

CAS No. : 96566-25-5

MCE 站：Ablukast

产品活性：Ablukast (Ro 23-3544) 是一种特异性的白三烯受体拮抗剂。Ablukast 可有效减少 LTC4 和抗原诱导的支气管狭窄。Ablukast 是一种 LTD4 受体拮抗剂.

研究领域：GPCR/G Protein

作用靶点：Leukotriene Receptor

In Vitro: Ablukast (Ro 23-3544) is tested for its efficacy in modulating dinitrofluorobenzene (DNFB)-induced allergic ａnd croton oil-induced irritant contact dermatitis in mouse ears. Treatment shortly after elicitation of the dermatitis, ａnd for up to 5 days thereafter, was moderately effective in suppressing DNFB-induced ear swelling in a dose-dependent fashion. Daily pre-treatment of the ears for 1 week causes a more marked reduction of DNFB-induced ear swelling during the first 48 h after elicitation.

In Vivo: Ablukast (Ro 23-3544) is tested for its efficacy in modulating dinitrofluorobenzene (DNFB)-induced allergic ａnd croton oil-induced irritant contact dermatitis in mouse ears. Treatment shortly after elicitation of the dermatitis, ａnd for up to 5 days thereafter, was moderately effective in suppressing DNFB-induced ear swelling in a dose-dependent fashion. Daily pre-treatment of the ears for 1 week causes a more marked reduction of DNFB-induced ear swelling during the first 48 h after elicitation.

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