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Dibromoacetic acid

CAS No. : 631-64-1

MCE 站：Dibromoacetic acid

产品活性：Dibromoacetic acid 是一种卤乙酸，常作为消毒副产品存在于饮用水中的，可引起许多不良反应，包括免疫毒性和诱导凋亡 (apoptosis) 等。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: Exposure to DBAA (5-40 μM) leads to significant reduction in thymocyte proliferation in vitro.
DBAA (5-40 μM; for 24 hours) treatment induced cell cycle arrest. The data showed at least 40% increase in the G₀/G₁ phase ａnd 50% decrease in the S phase in thymocytes treated with different concentrations of DBAA.
DBAA (5-40 μM; for 24 hours) decreases the expression of Bcl-2 ａnd increases the expression of Fas/FasL.

In Vivo: There is some evidence of carcinogenic activity of Dibromoacetic acid in male rats based on an increased incidence of malignant mesothelioma. The increased incidences of mononuclear cell leukemia in male rats may have been related to Dibromoacetic acid exposure.
There is some evidence of carcinogenic activity of Dibromoacetic acid in female rats based on an increased incidence ａnd positive trend of mononuclear cell leukemia.
There is clear evidence of carcinogenic activity of Dibromoacetic acid in male ａnd female mice based on increased incidences of hepatocellular neoplasms ａnd hepatoblastoma (males only). Increased incidences of lung neoplasms in male mice were also considered to be exposure related.

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